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  <xs:element id="lyel_AssetAcquisitionAssetsAcquiredIndefiniteLivedIntangibleAssets" abstract="false" name="AssetAcquisitionAssetsAcquiredIndefiniteLivedIntangibleAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_CollaborativeArrangementRightsAndObligationsStockPurchaseAgreementFairValuePerShare" abstract="false" name="CollaborativeArrangementRightsAndObligationsStockPurchaseAgreementFairValuePerShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="lyel_CollaborativeArrangementRightsAndObligationsCommercialMilestonePayments" abstract="false" name="CollaborativeArrangementRightsAndObligationsCommercialMilestonePayments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_StanfordSuccessPaymentLiabilityMember" abstract="true" name="StanfordSuccessPaymentLiabilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_SuccessPaymentLiabilityMeasurementInput" abstract="false" name="SuccessPaymentLiabilityMeasurementInput" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="lyel_CashEquivalentsFairValueDisclosureAndDebtSecuritiesAvailableForSale" abstract="false" name="CashEquivalentsFairValueDisclosureAndDebtSecuritiesAvailableForSale" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_LesseeOperatingLeasesArea" abstract="false" name="LesseeOperatingLeasesArea" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:areaItemType"/>
  <xs:element id="lyel_DescriptionOfOrganizationLineItems" abstract="true" name="DescriptionOfOrganizationLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="lyel_CollaborativeArrangementRightsAndObligationsStockPurchaseAgreementPurchasePricePerShare" abstract="false" name="CollaborativeArrangementRightsAndObligationsStockPurchaseAgreementPurchasePricePerShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="lyel_ShareBasedCompensationArrangementByShareBasedPaymentAwardIncreaseInNumberOfSharesAvailableForGrantPercentageOfSharesOutstanding" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardIncreaseInNumberOfSharesAvailableForGrantPercentageOfSharesOutstanding" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="lyel_TwoThousandTwentyOneEquityIncentivePlanMember" abstract="true" name="TwoThousandTwentyOneEquityIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_FredHutchMember" abstract="true" name="FredHutchMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_OtherEmployeeMember" abstract="true" name="OtherEmployeeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_SeriesAConvertiblePreferredStockMember" abstract="true" name="SeriesAConvertiblePreferredStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_CollaborativeArrangementRightsAndObligationsAggregatePotentialSuccessPayments" abstract="false" name="CollaborativeArrangementRightsAndObligationsAggregatePotentialSuccessPayments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_AssetAcquisitionAssetsAcquiredOtherAssets" abstract="false" name="AssetAcquisitionAssetsAcquiredOtherAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_OtherInvestmentMember" abstract="true" name="OtherInvestmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_CollaborativeArrangementRightsAndObligationsStockPurchaseAgreementSharesPurchased" abstract="false" name="CollaborativeArrangementRightsAndObligationsStockPurchaseAgreementSharesPurchased" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="lyel_CollaborativeArrangementRightsAndObligationsSuccessPaymentExpenseGain" abstract="false" name="CollaborativeArrangementRightsAndObligationsSuccessPaymentExpenseGain" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_CollaborativeArrangementRightsAndObligationsSuccessPaymentAgreementLiability" abstract="false" name="CollaborativeArrangementRightsAndObligationsSuccessPaymentAgreementLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_LesseeOperatingLeaseNumberOfContracts" abstract="false" name="LesseeOperatingLeaseNumberOfContracts" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="lyel_TemporaryEquityDeemedDividends" abstract="false" name="TemporaryEquityDeemedDividends" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_PaymentsOfUnderwritingDiscountsAndCommissions" abstract="false" name="PaymentsOfUnderwritingDiscountsAndCommissions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_CollaborativeArrangementRightsAndObligationsSuccessPaymentAgreementFairValueOfLiability" abstract="false" name="CollaborativeArrangementRightsAndObligationsSuccessPaymentAgreementFairValueOfLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_AccruedPropertyAndEquipmentCurrent" abstract="false" name="AccruedPropertyAndEquipmentCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_TwoThousandEighteenEquityIncentivePlanMember" abstract="true" name="TwoThousandEighteenEquityIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_TwentyTimesMember" abstract="true" name="TwentyTimesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_LyellImmunopharmaMember" abstract="true" name="LyellImmunopharmaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_AssetAcquisitionContingentConsiderationExpenseRecognized" abstract="false" name="AssetAcquisitionContingentConsiderationExpenseRecognized" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_StanfordMember" abstract="true" name="StanfordMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_AtTheMarketOfferingMember" abstract="true" name="AtTheMarketOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_ThirtyTimesMember" abstract="true" name="ThirtyTimesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumSharesIssuable" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumSharesIssuable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="lyel_ExpiresInJanuary2031Member" abstract="true" name="ExpiresInJanuary2031Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_DeferredTaxAssetsTaxCutsAndJobsActCapitalizedResearchAndDevelopment" abstract="false" name="DeferredTaxAssetsTaxCutsAndJobsActCapitalizedResearchAndDevelopment" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_ShareBasedPaymentArrangementOptionAndRestrictedStockMember" abstract="true" name="ShareBasedPaymentArrangementOptionAndRestrictedStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_SuccessPaymentLiabilitiesFairValueDisclosure" abstract="false" name="SuccessPaymentLiabilitiesFairValueDisclosure" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_ConsiderationReceivedEquitySecuritiesWithoutReadilyDeterminableFairValue" abstract="false" name="ConsiderationReceivedEquitySecuritiesWithoutReadilyDeterminableFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_ImmulusIncMember" abstract="true" name="ImmulusIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_AssetAcquisitionEquityInterestIssuedOrIssuableNumberOfShares" abstract="false" name="AssetAcquisitionEquityInterestIssuedOrIssuableNumberOfShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="lyel_FredHutchSuccessPaymentLiabilityMember" abstract="true" name="FredHutchSuccessPaymentLiabilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_TenTimesMember" abstract="true" name="TenTimesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_TemporaryEquityFairValueDisclosurePerShare" abstract="false" name="TemporaryEquityFairValueDisclosurePerShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="lyel_PACTPharmaIncMember" abstract="true" name="PACTPharmaIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_CollaborativeArrangementRightsAndObligationsAnnualLicenseMaintenancePayments" abstract="false" name="CollaborativeArrangementRightsAndObligationsAnnualLicenseMaintenancePayments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_CollaborativeArrangementRightsAndObligationsPotentialPaymentMultiplier" abstract="false" name="CollaborativeArrangementRightsAndObligationsPotentialPaymentMultiplier" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="lyel_DateOfEquityModificationsDomain" abstract="true" name="DateOfEquityModificationsDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_FiftyTimesMember" abstract="true" name="FiftyTimesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalSharesAuthorizedNumberOfSharesAsPercentageOfCommonSharesOutstanding" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalSharesAuthorizedNumberOfSharesAsPercentageOfCommonSharesOutstanding" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="lyel_GSKAgreementMember" abstract="true" name="GSKAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_DeferredTaxAssetsLeasingArrangements" abstract="false" name="DeferredTaxAssetsLeasingArrangements" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_CollaborativeArrangementRightsAndObligationsSuccessPaymentAgreementTerm" abstract="false" name="CollaborativeArrangementRightsAndObligationsSuccessPaymentAgreementTerm" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="lyel_PaymentsOfUpfrontPaymentsForResearchAndDevelopmentAgreement" abstract="false" name="PaymentsOfUpfrontPaymentsForResearchAndDevelopmentAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_EffectiveIncomeTaxRateReconciliationCollaborationRevenuePercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationCollaborationRevenuePercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="lyel_OperatingLossCarryforwardsSubjectToExpiration" abstract="false" name="OperatingLossCarryforwardsSubjectToExpiration" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_SeriesCConvertiblePreferredStockMember" abstract="true" name="SeriesCConvertiblePreferredStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="lyel_MonthlyFixedRentalPaymentProceeds" abstract="false" name="MonthlyFixedRentalPaymentProceeds" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_OtherInvestmentsPolicyPolicyTextBlock" abstract="false" name="OtherInvestmentsPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="lyel_CollaborativeArrangementRightsAndObligationsUpfrontPayment" abstract="false" name="CollaborativeArrangementRightsAndObligationsUpfrontPayment" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_StockIssuedDuringPeriodValueStrategicPartners" abstract="false" name="StockIssuedDuringPeriodValueStrategicPartners" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_AssetsAndLiabilitiesLesseeTableTextBlock" abstract="false" name="AssetsAndLiabilitiesLesseeTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="lyel_AccruedResearchAndDevelopmentExpensesCurrent" abstract="false" name="AccruedResearchAndDevelopmentExpensesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lyel_EquityMultipleDomain" abstract="true" name="EquityMultipleDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
